Methyl chlorodifluoroacetate

Names

[ Name ]:
Methyl chlorodifluoroacetate

[Synonym ]:
methyl 2-chloro-2,2-difluoroacetate
Acetic acid, 2-chloro-2,2-difluoro-, methyl ester
EINECS 216-154-9
Methyl chlorodifluoroacetate
Chlorodifluoroacetic acid methyl ester
Acetic acid, chlorodifluoro-, methyl ester
MFCD00000775
Methyl chloro(difluoro)acetate

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
80.0±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃H₃ClF₂O₂

[ Molecular Weight ]:
144.505

[ Flash Point ]:
19.4±0.0 °C

[ Exact Mass ]:
143.978958

[ PSA ]:
26.30000

[ LogP ]:
1.11

[ Vapour Pressure ]:
87.0±0.1 mmHg at 25°C

[ Index of Refraction ]:
1.359

[ Storage condition ]:
Flammables area

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H314

[ Precautionary Statements ]:
P210-P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F: Flammable;C: Corrosive;

[ Risk Phrases ]:
R11

[ Safety Phrases ]:
S16-S26-S36/37/39-S45

[ RIDADR ]:
UN 2924 3/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
II

[ Hazard Class ]:
3

[ HS Code ]:
2915900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2915900090

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

Articles

Methyl chlorodifluoroacetate a convenient trifluoromethylating agent. De-Bao S, et al.

Tetrahedron Lett. 32(52) , 7689-90, (1991)

Electrochemical, nickel-catalyzed Reformatsky reaction with methyl chlorodifluoroacetate Mcharek S, et al.

J. Organomet. Chem. 401(1) , 211-15, (1991)

Preparation of gem-difluorocyclopropanes via decomposition of methyl chlorodifluoroacetate by alkali metal halides. Wheaton GA and Burton DJ.

J. Fluor. Chem. 9(1) , 25-44, (1977)