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(S)-Seco-Duocarmycin SA

Names

[ CAS No. ]:
152785-82-5

[ Name ]:
(S)-Seco-Duocarmycin SA

[Synonym ]:
Methyl (8S)-8-(chloromethyl)-4-hydroxy-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-3,6,7,8-tetrahydropyrrolo[3,2-e]indole-2-carboxylate
Pyrrolo[3,2-e]indole-2-carboxylic acid, 8-(chloromethyl)-3,6,7,8-tetrahydro-4-hydroxy-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-, methyl ester, (8S)-

Biological Activity

[Description]:

(S)-Seco-Duocarmycin SA is a DNA alkylator, cytotoxic to cancer cells, and acts as a ADC cytotoxin for antibody-drug conjugates[1].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Tichenor MS, et al. Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity. J Am Chem Soc. 2007 Sep 5;129(35):10858-69.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
773.9±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H24ClN3O7

[ Molecular Weight ]:
513.927

[ Flash Point ]:
421.8±32.9 °C

[ Exact Mass ]:
513.130249

[ LogP ]:
1.54

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.691

Related Compounds