(2S,3S,4R,5R)-5-[6-[(4-amino-3-iodophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamide

Names

[ CAS No. ]:
152918-27-9

[ Name ]:
(2S,3S,4R,5R)-5-[6-[(4-amino-3-iodophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamide

[Synonym ]:
3-Iodo-4-aminobenzyl-5'-N-methylcarboxamidoadenosine
I-AB-MECA

Chemical & Physical Properties

[ Density]:
2.066g/cm3

[ Molecular Formula ]:
C18H20IN7O4

[ Molecular Weight ]:
525.30000

[ Exact Mass ]:
525.06200

[ PSA ]:
163.93000

[ LogP ]:
1.48490

[ Index of Refraction ]:
1.842

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

125I-4-aminobenzyl-5'-N-methylcarboxamidoadenosine, a high affinity radioligand for the rat A3 adenosine receptor.

Mol. Pharmacol. 45 , 978-982, (1994)

The rat A3 adenosine receptor (AR) is a recently characterized AR subtype cloned from testis and brain cDNA libraries. N6-2-(4-Amino-3-[125I]iodophenyl)ethyladenosine, a high affinity A1AR agonist, ha...

A role for central A3-adenosine receptors. Mediation of behavioral depressant effects.

FEBS Lett. 336 , 57-60, (1993)

The behavioral effects of a selective A3 adenosine receptor agonist 3-IB-MECA (N6-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine) in mice and the localization of radioligand binding sites in mouse bra...

The effects of adenosine A3 receptor stimulation on seizures in mice.

Eur. J. Pharmacol. 275 , 23-29, (1995)

We have previously shown that acute preischemic adenosine A3 receptor stimulation results in an increased postischemic damage, while chronic stimulation of this receptor diminishes it. Since several p...


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