U 74389G maleate
Names
[ CAS No. ]:
153190-29-5
[ Name ]:
U 74389G maleate
[Synonym ]:
MFCD01074991
Pregna-1,4,9(11)-triene-3,20-dione, 21-[4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]-, (2Z)-2-butenedioate (1:1)
21-{4-[2,6-Di(pyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}pregna-1,4,9(11)-triene-3,20-dione (2Z)-but-2-enedioate (1:1)
21-{4-[2,6-Di(1-pyrrolidinyl)-4-pyrimidinyl]-1-piperazinyl}pregna-1,4,9(11)-triene-3,20-dione (2Z)-2-butenedioate (1:1)
Biological Activity
[Description]:
[Related Catalog]:
[In Vitro]
[In Vivo]
[References]
Chemical & Physical Properties
[ Boiling Point ]:
811.6ºC at 760 mmHg
[ Molecular Formula ]:
C41H54N6O6
[ Molecular Weight ]:
726.904
[ Flash Point ]:
444.6ºC
[ Exact Mass ]:
726.410461
[ PSA ]:
147.48000
[ LogP ]:
5.05700
[ Vapour Pressure ]:
2.12E-26mmHg at 25°C
MSDS
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ RIDADR ]:
NONH for all modes of transport
Articles
Neuropharmacology 99 , 422-31, (2015)
Nitric oxide (NO) is involved in desensitization of μ-opioid receptors (MOR). We used extracellular recordings in vitro to unmask the NO-dependent pathways involved in MOR desensitization in the rat l...
Defective mitogen-activated protein kinase (ERK2) signaling in gastric mucosa of portal hypertensive rats: potential therapeutic implications.Hepatology 34(5) , 990-9, (2001)
Portal hypertensive (PHT) gastropathy is a frequent, serious complication of liver cirrhosis. PHT gastric mucosa has numerous abnormalities such as reduced mucosal potential differences, reduced surfa...
Copper-induced tissue factor expression in human monocytic THP-1 cells and its inhibition by antioxidants.Circulation 92 , 238, (1995)
Transition metals such as copper are known to initiate free radical formation and lipid peroxidation. Recent reports suggest that intracellular reactive oxygen intermediates can induce the transcripti...