N-[[(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-propan-2-ylamino]methyl]pyridine-3-carboxamide
Names
[ CAS No. ]:
15387-10-7
[ Name ]:
N-[[(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-propan-2-ylamino]methyl]pyridine-3-carboxamide
[Synonym ]:
Ra 101 (pharmaceutical)
Niprofazonum [INN-Latin]
1-Phenyl-2,3-dimethyl-4(N-nicotinamidomethyl-N-isopropyl)amino-5-pyrazolone
Nicotinamide,N-((antipyrinylisopropylamino)methyl)
Nicotinamidomethylaminopyrazolone
Niprofazona [INN-Spanish]
Niprofazone
RA 101
N-{[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-isopropyl-amino]-methyl}-nicotinamide
N-((Antipyrinylisopropylamino)methyl)nicotinamide
Chemical & Physical Properties
[ Density]:
1.25g/cm3
[ Molecular Formula ]:
C21H25N5O2
[ Molecular Weight ]:
379.45600
[ Exact Mass ]:
379.20100
[ PSA ]:
72.16000
[ LogP ]:
2.87260
[ Index of Refraction ]:
1.638
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QS4025000
- CHEMICAL NAME :
- Nicotinamide, N-((antipyrinylisopropylamino)methyl)-
- CAS REGISTRY NUMBER :
- 15387-10-7
- BEILSTEIN REFERENCE NO. :
- 0766712
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C21-H25-N5-O2
- MOLECULAR WEIGHT :
- 379.51
- WISWESSER LINE NOTATION :
- T6NJ CVM1NY1&1&- DT5NNVJ A1 BR& E1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1024,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1460 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1024,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1060 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1024,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 853 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1024,1970