Zinc protoporphyrin

Names

[ Name ]:
Zinc protoporphyrin

[Synonym ]:
Protoporphyrin IX zinc(II)
EINECS 239-455-7
21H,23H-Porphine-2,18-dipropanoic acid, 8,13-diethenyl-3,7,12,17-tetramethyl-, zinc salt (1:1)
MFCD00011612
[3,3'-(3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphyrindiyl-κN,N)dipropanoato(2-)]zinc
zinc 2,18-bis(2-carboxyethyl)-7,12-diethenyl-3,8,13,17-tetramethylporphine-21,23-diide
Zinc 2,18-bis(2-carboxyethyl)-3,7,12,17-tetramethyl-8,13-divinylporphine-21,23-diide
PROTOPORPHYRINATO ZINC
zinc,3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid
Zinc Protoporphyrin
Zinc, [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(2-)-κN,κN]-

Biological Activity

[Description]:

Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is a competitive heme oxygenase-1 (HO-1) inhibitor, markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2[1]. Zinc Protoporphyrin is a normal metabolite formed in trace amounts during heme biosynthesis and used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration[2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Research Areas >> Metabolic Disease

[References]

[1]. Park C, et al. Protective Effect of Phloroglucinol on Oxidative Stress-Induced DNA Damage and Apoptosisthrough Activation of the Nrf2/HO-1 Signaling Pathway in HaCaT Human Keratinocytes. Mar Drugs. 2019 Apr 13;17(4).

[2]. Mwangi MN, et al. Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan pregnant women. BMC Med. 2014 Nov 26;12:229.

Chemical & Physical Properties

[ Boiling Point ]:
1128.5ºC at 760mmHg

[ Molecular Formula ]:
C₃₄H₃₂N₄O₄Zn

[ Molecular Weight ]:
626.051

[ Flash Point ]:
636.3ºC

[ Exact Mass ]:
624.171509

[ PSA ]:
109.18000

[ LogP ]:
3.60970

[ Vapour Pressure ]:
0mmHg at 25°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Precursor & DownStream

Precursor

DownStream

Articles

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Toxicon 87 , 54-67, (2014)

Here we evaluated whether Natterins affect the leukocyte-endothelial cell interaction, hampering leukocyte mobilization and extravasation. Leukocyte-endothelial cell interactions were evaluated in ven...

Ramipril protects the endothelium from high glucose-induced dysfunction through CaMKKβ/AMPK and heme oxygenase-1 activation.

J. Pharmacol. Exp. Ther. 350(1) , 5-13, (2014)

This study aims to investigate the effects of ramipril (RPL) on endothelial dysfunction associated with diabetes mellitus using cultured human aortic endothelial cells (HAECs) and a type 2 diabetic an...

α-Tocopheryl succinate pre-treatment attenuates quinone toxicity in prostate cancer PC3 cells.

Gene 539(1) , 1-7, (2014)

α-Tocopheryl succinate is one of the most effective analogues of vitamin E for inhibiting cell proliferation and inducing cell death in a variety of cancerous cell lines while sparing normal cells or ...