BRD3308

Names

[ Name ]:
BRD3308

[Synonym ]:
BRD3308
Benzamide, 4-(acetylamino)-N-(2-amino-4-fluorophenyl)-
4-Acetamido-N-(2-amino-4-fluorophenyl)benzamide
MFCD30187588

Biological Activity

[Description]:

BRD3308 is a potent, selective HDAC3 inhibitor with IC50 of 54 nM, displays >20-fold selectivity over HDAC1 and HDAC2, >500-fold selectivity over other HDAC isoforms; attenuates PE-mediated phosphorylation of ERK, but not JNK; also activates HIV-1 transcription in the 2D10 cell line, induces outgrowth of HIV-1 from resting CD4+ T cells isolated from antiretroviral-treated, aviremic HIV+ patients ex vivo and disrupts HIV-1 latency; suppresses pancreatic β-cell apoptosis induced by inflammatory cytokines or glucolipotoxic stress, and increases functional insulin release.

[References]

References 1. Ferguson BS, et al. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9806-11. 2. Barton KM, et al. PLoS One. 2014 Aug 19;9(8):e102684. 3. Wagner FF, et al. ACS Chem Biol. 2016 Feb 19;11(2):363-74. View Related Products by Target HDAC

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
449.9±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₄FN₃O₂

[ Molecular Weight ]:
287.289

[ Flash Point ]:
225.9±28.7 °C

[ Exact Mass ]:
287.106995

[ LogP ]:
1.81

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.689