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PFM 01

Names

[ CAS No. ]:
1558598-41-6

[ Name ]:
PFM 01

[Synonym ]:
PFM01
4-Thiazolidinone, 5-[(4-hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-, (5Z)-
5-(4-Hydroxybenzylidene)-3-isobutyl-2-thioxothiazolidin-4-one
5-(4-Hydroxy-benzylidene)-3-isobutyl-2-thioxo-thiazolidin-4-one
(5Z)-5-(4-Hydroxybenzylidene)-3-isobutyl-2-thioxo-1,3-thiazolidin-4-one
(5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone
MFCD02220972

Biological Activity

[Description]:

PFM01 (SML1735) is a small molecule that specifically inhibits endonuclease, but not exonuclease activity of MRE11, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM, blocks the ssDNA-binding path toward the catalytic metal ions and disrupts endonuclease activity.

[References]

References 1. Shibata A, et al. Mol Cell. 2014 Jan 9;53(1):7-18. 2. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119. View Related Products by Target DNA Repair Protein

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
435.2±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C14H15NO2S2

[ Molecular Weight ]:
293.404

[ Flash Point ]:
217.0±31.5 °C

[ Exact Mass ]:
293.054413

[ LogP ]:
2.74

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.684

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds