noxytiolin

Names

[ CAS No. ]:
15599-39-0

[ Name ]:
noxytiolin

[Synonym ]:
Noxitiolinum
Noxyflex S
Noxytiolinum [INN-Latin]
EINECS 239-679-5
Noxythioline
Noxytiolin
Noxitolina [INN-Spanish]
Gynaflex
N-hydroxymethyl-N'-methylthiourea
noxythiolin
Noxytioline [INN-French]

Biological Activity

[Description]:

Noxytiolin (Noxythiolin) is an anti-infective agent and used for irrigation of the peritoneum[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Others >> Others

[In Vivo]

Noxytiolin (i.p.; 2mL) prevents adhesion formation[1]. Animal Model: Rats[1] Dosage: 2 mL Administration: i.p. Result: Reduced both the total and the mean number of adhesions formed and their mean length of attachment.

Chemical & Physical Properties

[ Density]:
1.223g/cm3

[ Boiling Point ]:
203.7ºC at 760 mmHg

[ Melting Point ]:
88-90°

[ Molecular Formula ]:
C3H8N2OS

[ Molecular Weight ]:
120.17300

[ Flash Point ]:
77ºC

[ Exact Mass ]:
120.03600

[ PSA ]:
76.38000

[ Vapour Pressure ]:
0.0659mmHg at 25°C

[ Index of Refraction ]:
1.564

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YT4980000
CHEMICAL NAME :
Urea, 1-(hydroxymethyl)-3-methyl-2-thio-
CAS REGISTRY NUMBER :
15599-39-0
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C3-H8-N2-O-S
MOLECULAR WEIGHT :
120.19
WISWESSER LINE NOTATION :
SUYM1&M1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2400 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 35,409,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MEIEDD Merck Index. (Merck & Co., Inc., Rahway, NJ 07065) 10th ed. 1983. For publisher information, see 85KYAH. Volume(issue)/page/year: 11,1064,1989

Safety Information

[ HS Code ]:
2930909090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%