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MIV-6R

Names

[ CAS No. ]:
1560968-55-9

[ Name ]:
MIV-6R

[Synonym ]:
4-(3-{4-[(R)-Amino(Cyclopentyl)phenylmethyl]piperidin-1-Yl}propoxy)benzonitrile
4-(3-{4-[(R)-Amino(cyclopentyl)phenylmethyl]-1-piperidinyl}propoxy)benzonitrile
Benzonitrile, 4-[3-[4-[(R)-aminocyclopentylphenylmethyl]-1-piperidinyl]propoxy]-

Biological Activity

[Description]:

A potent, ligand-efficient, and cell-active inhibitor menin-MLL interaction with IC50 of 56 nM, Kd of 85 nM; demonstrateds strong and selective effects in MLL leukemia cells, and induces more pronounced increase in CD11b expression in MLL-AF9 BMCs.

[References]

References 1. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14. 2. He S, et al. J Med Chem. 2014 Feb 27;57(4):1543-56. View Related Products by Target Histone Methyltransferase (HMTase)

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
591.4±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C27H35N3O

[ Molecular Weight ]:
417.586

[ Flash Point ]:
311.5±25.9 °C

[ Exact Mass ]:
417.278015

[ LogP ]:
5.70

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.601

Related Compounds