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G244-LM

Names

[ CAS No. ]:
1563007-08-8

[ Name ]:
G244-LM

[Synonym ]:
2-{4-[2-(Methylsulfonyl)phenyl]-1-piperazinyl}-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one
4H-Thiopyrano[4,3-d]pyrimidin-4-one, 3,5,7,8-tetrahydro-2-[4-[2-(methylsulfonyl)phenyl]-1-piperazinyl]-
G244-LM

Biological Activity

[Description]:

G244-LM is a potent and specific inhibitor of tankyrase 1/2 that inhibits Wnt signaling[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> PARP
Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[References]

[1]. Lau T, et al. A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth. Cancer Res. 2013 May 15;73(10):3132-44.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C18H22N4O3S2

[ Molecular Weight ]:
406.522

[ Exact Mass ]:
406.113342

[ LogP ]:
0.04

[ Index of Refraction ]:
1.727

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds