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Metesind glucuronate

Names

[ CAS No. ]:
157182-23-5

[ Name ]:
Metesind glucuronate

[Synonym ]:
4-((4-(((2-Aminobenz[cd]indol-6-yl)methylamino)methyl)phenyl)sulfonyl)morpholine mono-D-Glucuronate
Benz[cd]indole-2,6-diamine, N6-methyl-N6-[[4-(4-morpholinylsulfonyl)phenyl]methyl]-, compd. with β-D-glucopyranuronic acid (1:1)
N6-Methyl-N6-[4-(4-morpholinylsulfonyl)benzyl]benzo[cd]indole-2,6-diamine - β-D-glucopyranuronic acid (1:1)
4-((a-((2-Aminobenz[cd]indol-6-yl)methylamino)-p-tolyl)sulfonyl)morpholine mono-D-Glucuronate
Metesind glucuronate
N6-methyl-N6-[4-(morpholin-4-ylsulfonyl)benzyl]benzo[cd]indole-2,6-diamine - β-D-glucopyranuronic acid (1:1)

Biological Activity

[Description]:

Metesind glucuronate (AG 331;AG-265 glucuronate) is a potent thymidylate synthase (TS) inhibitor with IC50/IC90 of 0.7/3.0 uM; inhibits the cofactor binding site of TS, and accumulates in the S phase of the cell cycle in H35 cells at 10 uM. Brain Cancer Discontinued

[References]

References 1. Pressacco J, et al. Cancer Res. 1995 Apr 1;55(7):1505-8. 2. O'Connor BM, et al. Cancer Chemother Pharmacol. 1994;34(3):225-9. 3. Panadero A, et al. Oncol Res. 1995;7(2):73-81. View Related Products by Target Nucleoside Antimetabolite/Analog Brain Cancer

Chemical & Physical Properties

[ Molecular Formula ]:
C23H24N4O3SC6.H10O7

[ Molecular Weight ]:
630.666

[ Exact Mass ]:
630.199585

Related Compounds