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1,4-PBIT DIHYDROBROMIDE

Names

[ CAS No. ]:
157254-60-9

[ Name ]:
1,4-PBIT DIHYDROBROMIDE

[Synonym ]:
1,4-Phenylenedi-2,1-ethanediyl dicarbamimidothioate dihydrobromide
1,4-PB-ITU dihydrobromide
Carbamimidothioic acid, 1,4-phenylenedi-2,1-ethanediyl ester, hydrobromide (1:2)
1,4-Phenylenediethane-2,1-diyl dicarbamimidothioate dihydrobromide
1,4-PBIT dihydrobromide

Biological Activity

[Description]:

1,4-PBIT (1,4-PB-ITU) dihydrobromide (compound 46) is a potent nitric oxide synthases (NOS) inhibitor, with Ki values of 7.6 nM, 360 nM, and 16 nM for the inducible (iNOS), endothelial (eNOS), and neuronal (nNOS) isozymes, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> NO Synthase

[Target]

iNOS:7.6 nM (Ki)

eNOS:360 nM (Ki)

nNOS:16 nM (Ki)


[References]

[1]. E P Garvey, et al. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. J Biol Chem. 1994 Oct 28;269(43):26669-76.  

Chemical & Physical Properties

[ Molecular Formula ]:
C12H20Br2N4S2

[ Molecular Weight ]:
444.25

[ Exact Mass ]:
441.949585

[ PSA ]:
150.34000

[ LogP ]:
5.54120

Safety Information

[ Safety Phrases ]:
S22-S24/25

Related Compounds