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4-[6-(2-Fluoroethoxy)-2-quinolinyl]aniline

Names

[ CAS No. ]:
1573029-17-0

[ Name ]:
4-[6-(2-Fluoroethoxy)-2-quinolinyl]aniline

[Synonym ]:
4-[6-(2-Fluoroethoxy)-2-quinolinyl]aniline
Benzenamine, 4-[6-(2-fluoroethoxy)-2-quinolinyl]-
THK-523

Biological Activity

[Description]:

THK-523 has demonstrated its high affinity and selectivity for tau pathology both in vitro and in vivo. 18F-THK523 is a potent tau imaging radiotracer. 18F-THK523 is a potent in vivo tau imaging ligand for Alzheimer's disease[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[In Vivo]

THK-523 crosses the blood–brain barrier in mice and the in vivo retention rate in the brain of Tau transgenic mice increased[1]. Animal Model: Brain of tau transgenic mice[1] Dosage: 0.35 μg/kg Administration: Intravenous injection;25-30 mins Result: Overexpressed Tau in brain.

[References]

[1]. Ryuichi Harada, et al. Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology. Eur J Nucl Med Mol Imaging. 2013 Jan;40(1):125-32.

[2]. Michelle T Fodero-Tavoletti, 18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease. Brain. 2011 Apr;134(Pt 4):1089-100.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
470.3±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H15FN2O

[ Molecular Weight ]:
282.312

[ Flash Point ]:
238.2±28.7 °C

[ Exact Mass ]:
282.116852

[ LogP ]:
3.01

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.635

Related Compounds