BMS-871

Names

[ Name ]:
BMS-871

Biological Activity

[Description]:

BMS-871 is a potent, orally active pan-Notch inhibitor with IC50 of 4/1/4/3 nM for Notch1/2/3/4, respectively; inhibits TALL-1 tumor cell proliferation with IC50 of 4 nM, displays robust in vivo efficacy in Notch-dependent leukemia and triple negative breast cancer xenografts.

[References]

References 1. Shan W, et al. Bioorg Med Chem Lett. 2015 May 1;25(9):1905-9. View Related Products by Target Notch

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₂₇F₃N₄O₃

[ Molecular Weight ]:
536.555

Related Compounds

BMS-P5
BMS 599626 dihydrochloride
BMS-8
BMS-538203
BMS-794833
BMS-1001
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
2-(Bromomethyl)-3-(difluoromethyl)-6-(trifluoromethyl)pyridine-4-carbonyl chloride
4-Cyano-6-(difluoromethyl)-2-(trifluoromethyl)pyridine-3-carboxylic acid
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
[1-(4-Ethoxy-3-methoxyphenyl)cyclobutyl]methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
2-{[(4-Ethoxyphenyl)methyl]amino}acetaldehyde
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide