SC57666

Names

[ Name ]:
SC57666

[Synonym ]:
1-fluoro-4-(2-(4-methylsulfonylphenyl)-1-cyclopenten-1-yl)benzene
SC-57666
1-fluoro-4-[2-[4-(methylsulfonyl)phenyl]cyclopenten-1-yl] benzene
1-fluoro-4-(2-(4-(methanesulfonyl)phenyl)cyclopent-1-enyl)benzene
1-(4-methanesulphonylphenyl)-2-(4-fluorophenyl)cyclopentene
1-(2-(4-fluorophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene
SC57666

Biological Activity

[Description]:

SC57666 is a selective COX2 inhibitor with an IC50 of 26 nM.

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Target]

COX-2:26 nM (IC50)

[In Vitro]

SC57666 inhibits COX2 with an IC50 of 3.2±0.8 nM in CHO cells stably transfected with human COX isozymes, with 1000 fold or more selectivity over COX1 (IC50=6000±1900 nM)[2].

[In Vivo]

SC57666 has been shown to be orally active (ED50=1.7 mpk) in the adjuvant-induced arthritis model. No gastric lesions are observed in mice after 5 h when SC57666 is administered intragastrically at 600 mpk. No intestinal damage is observed in rats after 72 h when SC57666 is administered intragastrically at 200 mpk[1].

[References]

[1]. Reitz DB, et al. Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally activeCOX2 inhibitors. J Med Chem. 1994 Nov 11;37(23):3878-81.

[2]. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₇FO₂S

[ Molecular Weight ]:
316.39000

[ Exact Mass ]:
316.09300

[ PSA ]:
42.52000

[ LogP ]:
5.40470

[ Storage condition ]:
2-8℃