L-Methionine-DL-sulfoximine

Names

[ Name ]:
L-Methionine-DL-sulfoximine

[Synonym ]:
Butanoic acid, 2-amino-4-(S-methylsulfonimidoyl)-, (2S)-
L-S-(3-Amino-3-carboxypropyl)-S-methylsulfoximine
2-Amino-4-(S-methylsulfonimidoyl)butanoic acid
MFCD00002621
UNII:M9P6YZ6JX9
(2S)-2-Amino-4-(S-methylsulfonimidoyl)butanoic acid
L-Methionine sulfoximine

Biological Activity

[Description]:

L-Methionine-DL-sulfoximine (MSX) is an inhibitor of glutamine synthetase. L-Methionine-DL-sulfoximine is also a potent convulsant which metabolically and morphologically primarily affects astroglia.

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Albrecht J, Norenberg MD. L-methionine-DL-sulfoximine induces massive efflux of glutamine from cortical astrocytes in primary culture. Eur J Pharmacol. 1990;182(3):587-589.

[2]. Premakumar R, Sorger GJ, Gooden D. Repression of nitrate reductase in Neurospora studied by using L-methionine-DL-sulfoximine and glutamine auxotroph gln-1b. J Bacteriol. 1980;143(1):411-415.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
352.2±52.0 °C at 760 mmHg

[ Melting Point ]:
>210ºC (dec.)(lit.)

[ Molecular Formula ]:
C₅H₁₂N₂O₃S

[ Molecular Weight ]:
180.225

[ Flash Point ]:
166.8±30.7 °C

[ Exact Mass ]:
180.056870

[ PSA ]:
112.62000

[ LogP ]:
-1.38

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.560

[ Storage condition ]:
0-6°C

[ Stability ]:
Temperature Sensitive

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2925290090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2925290090

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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