Tetrahydrothiophene 1-oxide

Names

[ Name ]:
Tetrahydrothiophene 1-oxide

[Synonym ]:
TETRAHYDROTHIOPHENE-1-OXIDE
Tetramethylene Sulfoxide
Thiophene, tetrahydro-, 1-oxide
EINECS 216-493-2
thiolane 1-oxide
Tetrahydrothiophene 1-oxide
MFCD00005477

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
269.0±7.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄H₈OS

[ Molecular Weight ]:
104.171

[ Flash Point ]:
116.5±18.2 °C

[ Exact Mass ]:
104.029587

[ PSA ]:
36.28000

[ LogP ]:
-0.96

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.549

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XN0830000

CHEMICAL NAME :: Thiophene, tetrahydro-, 1-oxide

CAS REGISTRY NUMBER :: 1600-44-8

BEILSTEIN REFERENCE NO. :: 0105274

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C4-H8-O-S

MOLECULAR WEIGHT :: 104.18

WISWESSER LINE NOTATION :: T5STJ AO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IJRBA3 International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine. (Taylor & Francis Inc., 242 Cherry St., Philadelphia, PA 19106) V.1- 1959- Volume(issue)/page/year: 3,41,1961

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
XN0830000

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

The importance of alcohol dehydrogenase in regulation of ethanol metabolism in rat liver cells.

Biochem. J. 278 ( Pt 3) , 659-65, (1991)

We used titration with the inhibitors tetramethylene sulphoxide and isobutyramide to assess quantitatively the importance of alcohol dehydrogenase in regulation of ethanol oxidation in rat hepatocytes...

Inhibition by carboxamides and sulfoxides of liver alcohol dehydrogenase and ethanol metabolism.

J. Med. Chem. 26(6) , 916-22, (1983)

Sulfoxides and amides were tested as inhibitors of liver alcohol dehydrogenase and ethanol metabolism in rats. With both series of compounds, increasing the hydrophobicity resulted in better inhibitio...

Catalysis of peroxynitrite reactions by manganese and iron porphyrins.

Nitric Oxide 1(6) , 507-21, (1997)

Kinetics and products of peroxynitrite anion O=NOO- reactions, catalyzed by water-soluble manganese and iron porphyrins, were studied under basic and neutral conditions. In the absence of organic subs...