BPN14770

Names

[ Name ]:
BPN14770

[Synonym ]:
2-(4-{[2-(3-Chlorophenyl)-6-(trifluoromethyl)-4-pyrimidinyl]amino}phenyl)acetamide
Bpn-14770
Benzeneacetamide, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyrimidinyl]amino]-

Biological Activity

[Description]:

BPN14770 (BPN-14770) is an allosteric inhibitor of phosphodiesterase 4D (PDE4D) with IC50 of 7.8 and 7.4 nM for human PDE4D7 and PDE4D3 respectively, displays 16-fold less potent against monomeric form of PDE4D lacking the UCR1 dimerization domain (PDE4D2 IC50 = 127 nM); BPN14770 is 17-fold less potent against mouse PDE4D7 (IC50 = 133 nM), binds to a primate-specific, N-terminal region of PDE4D; elevates brain cAMP and facilitates hippocampal long-term potentiation (LTP) in wild-type and humanized PDE4D mice, improves cognitive performance, antagonized the amnesic effects of scopolamine and increased cAMP signaling in brain, and increased BDNF and markers of neuronal plasticity associated with memory. Other Indication Phase 2 Clinical

[References]

References 1. Zhang C, et al. Neuropsychopharmacology. 2018 Oct;43(11):2299-2309. 2. Gurney ME, et al. Handb Exp Pharmacol. 2011;(204):167-92. 3. Gurney ME, et al. Sci Rep. 2017 Nov 7;7(1):14653. View Related Products by Target Phosphodiesterase (PDE) Other Indication

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
511.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₄ClF₃N₄O

[ Molecular Weight ]:
406.789

[ Flash Point ]:
263.1±30.1 °C

[ Exact Mass ]:
406.080811

[ LogP ]:
3.30

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.611

BPN14770

Names

Biological Activity

Chemical & Physical Properties

Related Compounds