BAY-747
Names
[ CAS No. ]:
1609341-78-7
[ Name ]:
BAY-747
Biological Activity
[Description]:
BAY-747 (BAY747) is a novel potent, selective, brain-penetrant soluble guanylate cyclase (sGC) stimulator.Oral administration of BAY-747 to male Wistar rats enhanced memory acquisition in the object location task (OLT), reversed L-NAME induced memory impairments in the OLT.BAY-747 enhanced hippocampal GluA1-containing AMPA receptor (AMPAR) trafficking in a chemical LTP model for memory acquisition using acute mouse hippocampal slices in ex vivo.
[References]
1. Nelissen E, et al. Sci Rep. 2022 Mar 4;12(1):3589.
Chemical & Physical Properties
[ Molecular Formula ]:
C22H26F2N4O2
[ Molecular Weight ]:
416.473