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ACY-957

Names

[ CAS No. ]:
1609389-52-7

[ Name ]:
ACY-957

[Synonym ]:
6-Quinolinecarboxamide, N-[2-amino-5-(2-thienyl)phenyl]-2-(1-piperazinyl)-
N-[2-Amino-5-(2-thienyl)phenyl]-2-(1-piperazinyl)-6-quinolinecarboxamide

Biological Activity

[Description]:

ACY-957 is a selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9.

[Related Catalog]:

Research Areas >> Others

[Target]

HDAC1:7 nM (IC50)

HDAC2:18 nM (IC50)

HDAC3:1300 nM (IC50)


[In Vitro]

ACY-957 is a selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9. ACY-957 has an IC50 of 304 nM for HDAC2 in primary hematopoietic progenitors[1].

[References]

[1]. Shearstone JR, et al. Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2. PLoS One. 2016 Apr 13;11(4):e0153767.


[Related Small Molecules]

Trichostatin A | Entinostat (MS-275) | Romidepsin (FK228, Depsipeptide) | Mocetinostat(MGCD0103) | Ricolinostat (ACY-1215) | Sodium butyrate | RGFP 966 | Quisinostat | Tubacin | DL-Sulforaphane | CUDC-907 | LMK 235 | CI-994 | Tubastatin A | Sodium phenylbutyrate

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
602.7±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H23N5OS

[ Molecular Weight ]:
429.537

[ Flash Point ]:
318.3±31.5 °C

[ Exact Mass ]:
429.162323

[ LogP ]:
2.73

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.726

[ Storage condition ]:
2-8℃

Related Compounds