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HA-15

Names

[ CAS No. ]:
1609402-14-3

[ Name ]:
HA-15

[Synonym ]:
N-{4-[3-({[5-(Dimethylamino)-1-naphthyl]sulfonyl}amino)phenyl]-1,3-thiazol-2-yl}acetamide
Acetamide, N-[4-[3-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-thiazolyl]-
HA15
HA-15

Biological Activity

[Description]:

HA15 is a molecule that targets specifically BiP/GRP78/HSPA5target: BiP, GRP78, HSPA5 [1]In vitro: HA15 induces ER stress leading to cancer cell death. kills cancer cells by targeting BiP to increase ER stress, leading to melanoma cell death by concomitant induction of autophagic and apoptotic mechanisms. HA15 exhibits strong efficacy in melanoma cells. The 50% inhibitory concentration (IC50) in A375 cells was between 1 and 2.5 mM HA15. [1]In vivo: HA15 induces ER stress leading to cancer cell death. HA15 also exhibited strong efficacy in xenograft mouse models with melanoma cellseither sensitive or resistant to BRAF inhibitors. [1]

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Cancer

[References]

[1]. Cerezo M et al. Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance. Cancer Cell. 2016 Jun 13;29(6):805-19.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C23H22N4O3S2

[ Molecular Weight ]:
466.576

[ Exact Mass ]:
466.113342

[ LogP ]:
4.56

[ Index of Refraction ]:
1.701

[ Storage condition ]:
-20℃

Related Compounds