NU 2058

Names

[ Name ]:
NU 2058

[Synonym ]:
7H-Purin-2-amine, 6-(cyclohexylmethoxy)-
MFCD05664734
6-(Cyclohexylmethoxy)-3H-purin-2-amine
O-Cyclohexylmethylguanine
O6-Cinnamylguanin
O6-Cyclohexylmethylguanine
2-amino-6-cyclohexylmethoxypurine
O6cyclohexylmethylguanine
NU2058

Biological Activity

[Description]:

NU2058 is a guanine-based CDK inhibitor with IC50 of 17 μM and 26 μM for CDK2 and CDK1.IC50 value: 17μM (CDK2), 26μM (CDK1)Target: CDKin vitro: NU2058 is a competitive inhibitor of CDK2 with respect to ATP (Ki value CDK2, 12 3 μM) that binds in the ATP binding pocket in a different orientation from other purine-based inhibitors, including olomoucine and roscovotine. NU2058 is the lead compound in a structure-based drug discovery program to develop more potent and selective CDK inhibitors.

[Related Catalog]:

Research Areas >> Cancer

[Target]

CDK2:17 μM (IC50)

CDK1:26 μM (IC50)

[References]

[1]. Rigas AC, et al. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer. Oncogene. 2007 Dec 6;26(55):7611-7619.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
580.8±53.0 °C at 760 mmHg

[ Melting Point ]:
199 °C

[ Molecular Formula ]:
C₁₂H₁₇N₅O

[ Molecular Weight ]:
247.296

[ Flash Point ]:
305.0±30.9 °C

[ Exact Mass ]:
247.143311

[ PSA ]:
89.71000

[ LogP ]:
2.89

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.650

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26;S36/S37

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%