isosorbide 2-mononitrate

Names

[ Name ]:
isosorbide 2-mononitrate

[Synonym ]:
2-Ismn
Glucitol,1,4:3,6-dianhydro-,2-nitrate,D
1,4:3,6-Dianhydrosorbitol 2-mononitrate
Isosorbide-5-nitrate
isosorbide-5-mononitrate
Isosorbide 2-nitrate
Isosorbide-2-mononitrate
1,4:3,6-Dianhydro-D-glucitol 2-nitrate

Chemical & Physical Properties

[ Density]:
1.56g/cm3

[ Boiling Point ]:
364.5ºC at 760mmHg

[ Melting Point ]:
>51.5°C

[ Molecular Formula ]:
C₆H₉NO₆

[ Molecular Weight ]:
191.13900

[ Flash Point ]:
174.2ºC

[ Exact Mass ]:
191.04300

[ PSA ]:
93.74000

[ Vapour Pressure ]:
8.66E-07mmHg at 25°C

[ Index of Refraction ]:
1.542

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ4385500

CAS REGISTRY NUMBER :: 16106-20-0

LAST UPDATED :: 199206

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H9-N-O6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 33,1117,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 33,1117,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 19,4947,1985

Safety Information

[ Hazard Codes ]:
F

[ RTECS ]:
LZ4385500

Articles

Effects of isosorbide-5-mononitrate and isosorbide-2-mononitrate on isolated dog aorta: vascular relaxation and increase in cyclic GMP.

Arch. Int. Pharmacodyn. Ther. 312 , 104-9, (1991)

The effects of isosorbide-5-mononitrate (IS-5-MN) and isosorbide-2-mononitrate (IS-2-MN) on vascular smooth muscle tone and on cyclic nucleotide levels were studied in isolated dog aorta. The effects ...

Pharmacokinetic/pharmacodynamic relationship of the duration of vasodilating action of organic mononitrates in rats.

J. Pharmacol. Exp. Ther. 261(2) , 692-700, (1992)

Conflicting information existed regarding the relevance of pharmacokinetics in relation to the duration of action of organic nitrates. We examined this question using three geometric isomers of organi...

[Study of the bioequivalence of a new isosorbide dinitrate tablet formulation compared with the standard preparation].

Arzneimittelforschung 47(6) , 719-26, (1997)

An investigation in the bioequivalence of a new tablet formulation with 5 mg isosorbide dinitrate (CAS 87-33-2, ISDN 5 von ct) was performed in a two-way cross-over study with 18 subjects. The relativ...