ML336

Names

[ Name ]:
ML336

[Synonym ]:
ML-336
MFCD28160682
Benzamide, 2-[[(2E)-1,4-dimethyl-2-piperazinylidene]amino]-5-nitro-N-phenyl-
2-[(E)-(1,4-Dimethyl-2-piperazinylidene)amino]-5-nitro-N-phenylbenzamide

Biological Activity

[Description]:

ML336 is quinazolinone-based inhibitor against venezuelan equine encephalitis virus (VEEV), with IC50s of 32, 20, and 42 nM for VEEV TC-83 CPE , VEEV V3526 CPE, VEEV Wild Type CPE, respectively. ML336 potently inhibits a VEEV-induced cytopathic effect in three strains of the virus (TC-83, V3526, and wild type Trinidad donkey) in the low nanomolar range[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Chung D, et al. ML336: Development of Quinazolinone-Based Inhibitors Against Venezuelan Equine Encephalitis Virus (VEEV). 2012 Dec 17 [updated 2013 Nov 7]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–.

[2]. Donghoon Chung 1, et al. ML336: Development of Quinazolinone-Based Inhibitors Against Venezuelan Equine Encephalitis Virus (VEEV).

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₁₉H₂₁N₅O₃

[ Molecular Weight ]:
367.402

[ Exact Mass ]:
367.164429

[ LogP ]:
2.50

[ Index of Refraction ]:
1.640