MCAAD-3

Names

[ CAS No. ]:
1625629-51-7

[ Name ]:
MCAAD-3

[Synonym ]:
methyl(2Z,4E,6E)-2-cyano-7-[4-(dimethylamino)]hepta-2,4,6-trienoate

Biological Activity

[Description]:

MCAAD-3 is a near-infrared Aβ imaging probe with blood-brain barrier penetrability. MCAAD-3 has a strong affinity for Aβ polymers (Ki >106 nM) and can label Aβ plaques in the brains of transgenic mice[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Fu H, et al. Evaluation of molecules based on the electron donor-acceptor architecture as near-infrared β-amyloidal-targeting probes. Chem Commun (Camb). 2014 Oct 14;50(80):11875-8.  

Chemical & Physical Properties

[ Water Solubility ]:
Soluble in DMSO to 100 mM

Related Compounds