Nerelimomab

Names

[ CAS No. ]:
162774-06-3

[ Name ]:
Nerelimomab

Biological Activity

[Description]:

Nerelimomab (BAYX1351) is an anti-TNF-α antibody. Nerelimomab can be used for research of sepsis[1][2].

[Related Catalog]:

Research Areas >> Infection

[In Vivo]

Nerelimomab (7.5 mg/kg，静脉输注) 在复发性菌血症的狒狒模型中保护动物免于死亡[1]。 Animal Model: Baboon model of recurrent bacteremia (Challenged with E.coli)[1] Dosage: 7.5 mg/kg Administration: i.v. infusion Result: Improved organ function and attenuated cytokine and plasminogen activator inhibitor release.

[References]

[1]. Schlag G, et al. Anti-tumor necrosis factor antibody treatment of recurrent bacteremia in a baboon model. Shock. 1994 Jul;2(1):10-8; discussion 19-22.

[2]. Cohen J, et al. INTERSEPT: an international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group. Crit Care Med. 1996 Sep;24(9):1431-40.

Chemical & Physical Properties

No Any Chemical & Physical Properties