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Domagrozumab

Names

[ CAS No. ]:
1629605-31-7

[ Name ]:
Domagrozumab

Biological Activity

[Description]:

Domagrozumab is an anti-myostatin humanized monoclonal antibody with a KD value of 2.6 pM for human myostatin. Domagrozumab induces muscle anabolic activity. Domagrozumab can be used in research of duchenne muscular dystrophy (DMD)[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[In Vitro]

Domagrozumab (PF-06252616) 抑制人肌肉生长抑制素信号传导活性，IC50 值 为 < 1 nM[1]。

[In Vivo]

Domagrozumab (PF-06252616; 10 and 30 mg/kg; i.v.) 以剂量依赖性方式增加肌肉生长抑制素水平并诱导食蟹猴骨骼肌肥大[1]。

[References]

[1]. St Andre M, et, al. A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys. Skelet Muscle. 2017 Nov 9;7(1):25.  

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds