ML379
Names
[ CAS No. ]:
1630760-58-5
[ Name ]:
ML379
Biological Activity
[Description]:
ML379 (CID71576758) is a potent, selective TP53 mutant cancer cells inhibitor with IC50 of 13 nM in sensitive HeLa cells (TP53 mutant); displays >1,000-fold selectivity over insensitive A549 cells (TP53 wild type); displays low nM activity in a larger panel of TP53 mutant cell lines.
[References]
References 1. Lewis TA, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. View Related Products by Target MDM2-p53
Chemical & Physical Properties
[ Molecular Formula ]:
C15H19N3O2
[ Molecular Weight ]:
273.33