PNR-7-02

PNR-7-02 is a specific inhibitor of human DNA Polymerase η (hPol η) with IC50 of 8 uM, exhibits 5-10-fold specificity for hPol η over other replicative Pols; binds to a site on the little finger domain and interferes with the proper orientation of template DNA to inhibit hpol η; potentiates the effects of cisplatin in tumor cells accompanied with increased γH2AX formation.

References 1. Zafar MK, et al. Biochemistry. 2018 Feb 20;57(7):1262-1273. View Related Products by Target DNA/RNA Synthesis