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Fosnetupitant chloride monohydrochloride

Names

[ CAS No. ]:
1643757-72-5

[ Name ]:
Fosnetupitant chloride monohydrochloride

Biological Activity

[Description]:

Fosnetupitant chloride monohydrochloride (Pronetupitant chloride monohydrochloride) is an NK1 antagonist with pKi values of 9.5, 6.1 for human NK1 and NK3 receptor, respectively. Fosnetupitant chloride monohydrochloride is a methylene phosphate prodrug of Netupitant[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor
Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[Target]

hNK1:9.5 (pKi)

hNK3:6.1 (pKi)


[References]

[1]. Ruzza C, et al. In vitro and in vivo pharmacological characterization of Pronetupitant, a prodrug of the neurokinin 1 receptor antagonist Netupitant. Peptides. 2015 Jul;69:26-32.  

Chemical & Physical Properties

[ Molecular Formula ]:
C31H37Cl2F6N4O5P

[ Molecular Weight ]:
761.52

Related Compounds