HH-N25

Names

[ Name ]:
HH-N25

Biological Activity

[Description]:

HH-N25 is a a potent and selective topoisomerase I (TOP1) inhibitor with potent antiproliferative activities against a panel of human breast cancer cell lines (IC50=0.045-4.2 uM).HH-N25 shows potent antitumor activities in human breast cancer cells in vitro and in vivo.

[References]

1. Bashir Lawal, et al. J Inflamm Res. 2021 Sep 22;14:4901-4913.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₁₅ClN₂Os

[ Molecular Weight ]:
402.896

Related Compounds

Hh-Ag1.5
(S)-HH-Phos
3-(butylamino)-4-chloro-5-sulfamoylbenzoic acid
N1,N2-Methylenelunarinol I
JK184
MMP Inhibitor II
2-[(3-Oxo-3,4-dihydro-2h-1,4-benzoxazine-6-yl)carbonyl]-n-phenylbenzamide
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide