DC-cholesterol hydrochloride

Names

[ Name ]:
DC-cholesterol hydrochloride

[Synonym ]:
2,3-dihydroxypropyl dihydrogen phosphate-cyclohexanamine(2:1)
DC-cholesterol hydrochloride
marinobufotoxin
3β-[N-(Dimethylaminoethane)carbamoyl]cholesterol
O-[(N,N-Dimethylaminoethyl)-carbamoyl]cholesterol hydrochloride

Biological Activity

[Description]:

DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Esmail A Elbassal, et al. Effects of Charged Cholesterol Derivatives on Aβ40 Amyloid Formation. J Phys Chem B. 2016 Jan 14;120(1):59-68.

[2]. Richard Lantz, et al. Effects of disulfide bond and cholesterol derivatives on human calcitonin amyloid formation. Biopolymers. 2020 May;111(5):e23343.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₂H₅₇ClN₂O₂

[ Molecular Weight ]:
537.26000

[ Exact Mass ]:
536.41100

[ PSA ]:
45.06000

[ LogP ]:
8.69060

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

In vitro liposome-mediated DNA transfection of epithelial cell lines using the cationic liposome DC-Chol/DOPE.

Gene Ther. 2 , 603-613, (1995)

Clinical trials using cationic liposome-mediated DNA transfer have now been initiated for several disorders including cystic fibrosis. Previous studies have shown that the level of gene expression ach...

Lipofection reagents prepared by a simple ethanol injection technique.

Biotechniques 18 , 1027-1032, (1995)

Cationic liposomes are being utilized for the delivery of DNA into mammalian cells both in vitro and in vivo. In this report, we describe a rapid, simple injection method for the preparation of cation...

The use of cationic liposomes DC-CHOL/DOPE and DDAB/DOPE for direct transfer of Escherichia coli cytosine deaminase gene into growing melanoma tumors.

Gene Ther. 3 , 1026-1031, (1996)

An attempt was made to use simple cationic liposomes DC-Chol/DOPE and DDAB/DOPE (DC-Chol is 3 beta (N(N',N-dimethylaminoethane) carbamoyl) cholesterol, DDAB is dimethyldioctadecyl ammonium bromide and...