(20R)-17,20-Dihydroxypregn-4-en-3-one

Names

[ Name ]:
(20R)-17,20-Dihydroxypregn-4-en-3-one

[Synonym ]:
(20R)-17,20-Dihydroxypregn-4-en-3-one
17ALPHA,20BETA-DIHYDROXY-4-PREGNEN-3-ONE
Pregn-4-en-3-one, 17,20-dihydroxy-, (20R)-
4-Pregnen-17α,20β-diol-3-one
MFCD00010485

Biological Activity

[Description]:

17α,20β-Dihydroxy-4-pregnen-3-one (17,20β-P) is a maturation-inducing steroid[1].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> Others >> Others

[References]

[1]. J V Planas, et al. Maturation-associated changes in the response of the salmon testis to the steroidogenic actions of gonadotropins (GTH I and GTH II) in vitro. Biol Reprod. 1995 Mar;52(3):697-704.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
487.1±45.0 °C at 760 mmHg

[ Melting Point ]:
201-202ºC

[ Molecular Formula ]:
C₂₁H₃₂O₃

[ Molecular Weight ]:
332.48

[ Flash Point ]:
262.5±25.2 °C

[ Exact Mass ]:
332.235138

[ PSA ]:
57.53000

[ LogP ]:
2.88

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.568

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Precursor & DownStream

Precursor

DownStream

Articles

Changes in expression of genes encoding gonadotropin subunits and growth hormone/prolactin/somatolactin family hormones during final maturation and freshwater adaptation in prespawning chum salmon.

Endocrine 20(1-2) , 23-34, (2003)

The pituitary levels of mRNAs encoding gonadotropin (GTH) subunits (GTH alpha2 and IIbeta), prolactin (PRL), and somatolactin (SL) increased in chum salmon during the last stages of spawning migration...

Dispersion of cyclin B mRNA aggregation is coupled with translational activation of the mRNA during zebrafish oocyte maturation.

Dev. Biol. 229(2) , 421-31, (2001)

Cyclin B mRNA stored in immature zebrafish oocytes is translationally activated upon the stimulation of 17alpha,20beta-dihydroxy-4-pregnen-3-one (17alpha,20beta-DP), an event prerequisite for initiati...

Epidermal growth factor receptor binding and biological activity in the ovary of goldfish, Carassius auratus.

Am. J. Physiol. 270(5 Pt 2) , R1065-72, (1996)

The receptor binding and biological activity of epidermal growth factor-urogastrone (EGF) was characterized in the follicle-enclosed goldfish oocyte. The binding of 125I-labeled mouse EGF (mEGF) to go...