Drofenine
Names
[ CAS No. ]:
1679-76-1
[ Name ]:
Drofenine
[Synonym ]:
2-Cyclohexyl-2-phenyl-essigsaeure-(2-diethylamino-ethylester)
hexahydroadiphenine
Trasentine 6H
Drofenina [INN-Spanish]
Cyclohexyl-phenyl-essigsaeure-(2-diaethylamino-aethylester)
Drofeninum [INN-Latin]
Adiphenine H
cyclohexyl-phenyl-acetic acid-(2-diethylamino-ethyl ester)
drofenine
Cycloadiphene
(+/-)-Cyclohexyl-phenyl-essigsaeure-(2-diethylamino-ethylester)
Drofenine [INN-French]
Cycloadiphenine
Chemical & Physical Properties
[ Density]:
1.018g/cm3
[ Boiling Point ]:
417.4ºC at 760mmHg
[ Molecular Formula ]:
C20H31NO2
[ Molecular Weight ]:
317.46600
[ Flash Point ]:
124.6ºC
[ Exact Mass ]:
317.23500
[ PSA ]:
29.54000
[ LogP ]:
4.23550
[ Vapour Pressure ]:
3.55E-07mmHg at 25°C
[ Index of Refraction ]:
1.519
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GU6780000
- CHEMICAL NAME :
- Cyclohexaneacetic acid, alpha-phenyl-, 2-(diethylamino)ethyl ester
- CAS REGISTRY NUMBER :
- 1679-76-1
- BEILSTEIN REFERENCE NO. :
- 2059173
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C20-H31-N-O2
- MOLECULAR WEIGHT :
- 317.52
- WISWESSER LINE NOTATION :
- L6TJ AYR&VO2N2&2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1600 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - ulceration or bleeding from stomach
- REFERENCE :
- APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam, Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ. Volume(issue)/page/year: 1,4,1950
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1600 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam, Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ. Volume(issue)/page/year: 1,4,1950
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 37 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AJDDAL American Journal of Digestive Diseases. (New York, NY) V.5-22, 1938-55; New series: V.1-23, 1956-78. For publisher information, see DDSCDJ. Volume(issue)/page/year: 18,241,1951
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness
- REFERENCE :
- BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 14,559,1959
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam, Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ. Volume(issue)/page/year: 1,4,1950
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam, Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ. Volume(issue)/page/year: 1,4,1950
Safety Information
[ HS Code ]:
2922199090
Customs
[ HS Code ]: 2922199090
[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%