ODN 24987

Names

[ CAS No. ]:
1682661-48-8

[ Name ]:
ODN 24987

Biological Activity

[Description]:

ODN 24987 is a Guanine-modified inhibitory oligonucleotides (ODN), targeting TLR9. ODN 24987 can inhibit IL-6 and IFN-α release. ODN 24987 can be used for research immune disorders. ODN 24987 sequence: 5’-C-C-T-G-G-C-c7G-G-G-G-3’[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)
Research Areas >> Inflammation/Immunology

[Target]

TLR9


[In Vitro]

ODN 24987 (0.1, 1 and 10 μM, 24 h) impairs efficiently TLR9-mediated release of IFN-α by PBMCs, and prevents IL-6 release by CpG-ODN-activated human B-cells[1]. ODN 24987 (0.01, 0.1, 1, 10 μM; 48 h) impairs Imiquimod-induced IL-6 release by human PBMCs[1].

[References]

[1]. Römmler F, et al. Guanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated immune responses of human immune cells. PLoS One. 2015 Feb 19;10(2):e0116703.

[2]. Römmler F, et al. Guanine modification of inhibitory oligonucleotides potentiates their suppressive function. J Immunol. 2013 Sep 15;191(6):3240-53.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds