PU-141
Names
[ CAS No. ]:
168334-34-7
[ Name ]:
PU-141
Biological Activity
[Description]:
PU-141 is a potent, selective CBP/p300 inhibitor that inhibits SK-N-SH cell growth with GI50 of 0.48 uM; blocks growth of SK-N-SH neuroblastoma xenografts in mice, also reduces histone lysine acetylation in vivo at concentrations that block neoplastic xenograft growth.
[References]
References 1. Gajer JM, et al. Oncogenesis. 2015 Feb 9;4:e137. 2. Furdas SD, et al. Bioorg Med Chem. 2011 Jun 15;19(12):3678-89. View Related Products by Target Histone Acetyltransferase (HAT)
Chemical & Physical Properties
[ Molecular Formula ]:
C14H9F3N2OS
[ Molecular Weight ]:
310.294
Safety Information
[ Hazard Codes ]:
Xi