Nitroxynil

Names

[ Name ]:
Nitroxynil

[Synonym ]:
MFCD00070776
Dovenix
Nitroxynil
Benzonitrile, 4-hydroxy-3-iodo-5-nitro-
4-Hydroxy-3-iodo-5-nitrobenzonitrile
EINECS 216-884-8

Biological Activity

[Description]:

Nitroxynil, anthelmintic agent, is active against parasites in both adult and immature stages. Nitroxynil is widely used for the research of infection of Fasciola hepatica[1][2][3].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Holsback L, et, al. Anthelmintic efficiency of doramectin, fenbendazole, and nitroxynil, in combination or individually, in sheep worm control. Rev Bras Parasitol Vet. Jul-Sep 2016;25(3):353-8.

[2]. Takeba K, et, al. [Investigation of the residue of the fasciolicide nitroxynil in milk and dairy products]. Nihon Koshu Eisei Zasshi. 1992 Feb;39(2):75-82.

[3]. Na G, et, al. A rapid colloidal gold-based immunochromatographic strip assay for monitoring nitroxynil in milk. J Sci Food Agric. 2020 Mar 30;100(5):1860-1866.

Chemical & Physical Properties

[ Density]:
2.2±0.1 g/cm3

[ Boiling Point ]:
280.1±40.0 °C at 760 mmHg

[ Melting Point ]:
136 - 139ºC

[ Molecular Formula ]:
C₇H₃IN₂O₃

[ Molecular Weight ]:
290.015

[ Flash Point ]:
123.2±27.3 °C

[ Exact Mass ]:
289.918823

[ PSA ]:
89.84000

[ LogP ]:
2.80

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.736

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DI4600000

CHEMICAL NAME :: Benzonitrile, 4-hydroxy-3-iodo-5-nitro-

CAS REGISTRY NUMBER :: 1689-89-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H3-I-N2-O3

MOLECULAR WEIGHT :: 290.02

WISWESSER LINE NOTATION :: WNR BQ CI ECN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973

Safety Information

[ Symbol ]:

GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H317-H319-H335-H400

[ Precautionary Statements ]:
P261-P273-P280-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R25;R36/37/38;R43

[ Safety Phrases ]:
S26-S36/37-S45

[ RIDADR ]:
UN2811 6.1/PG 3

[ RTECS ]:
DI4600000

[ HS Code ]:
2926909090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2926909090

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

In vitro metabolism of aromatic nitriles.

J. Pharm. Sci. 83(12) , 1729-34, (1994)

Studies on the metabolic fate of aromatic nitriles, in contrast to their aliphatic counterparts, have been minimal and the subject of controversy. The in vitro metabolic fate of several aromatic nitri...

Efficacy of an injectable combination anthelmintic (nitroxynil+clorsulon+ivermectin) against early immature Fasciola hepatica compared to triclabendazole combination flukicides given orally or topically to cattle.

Vet. Parasitol. 162(3-4) , 278-84, (2009)

The objective was to compare the efficacy against artificially induced 2- and 4-week old early immature triclabendazole-susceptible liver flukes (Fasciola hepatica) of an injectable combination of nit...

Determination of nitroxynil residues in tissues using high-performance liquid chromatography-thermospray mass spectrometry.

Analyst 114(9) , 1013-5, (1989)

A method is described for the determination of nitroxynil residues in muscle, liver and kidney. The samples were extracted into diethyl ether and cleaned-up using a simple liquid-liquid extraction ste...