Platinum,diamminetetrachloro-, (OC-6-22)-

Names

[ Name ]:
Platinum,diamminetetrachloro-, (OC-6-22)-

[Synonym ]:
trans-[PtCl4(NH3)2]
Tetrachloro-trans-diammin-platin(IV)
diamminetetrachloroplatinum
(z)-platinum(iv
Tetrachlorodiammineplatinum
EINECS 240-930-6
(oc-6-22)-platinu
MFCD00050045
pt-09
trans-[Pt(NH3)2Cl4]
DIAMMINETETRACHLOROPLATINATE (IV)
{Pt<a2>Cl4}
cis Tetrachlorodiammine platinum
cis-diamminotetrachloroplatinum
trans-diamminetetrachloroplatinum(IV)
cis-platinumdiamminetetrachloride

Chemical & Physical Properties

[ Melting Point ]:
>300ºC(lit.)

[ Molecular Formula ]:
Cl₄H₄N₂Pt

[ Molecular Weight ]:
368.93500

[ Exact Mass ]:
366.87800

[ PSA ]:
52.04000

[ LogP ]:
2.97490

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TP2485803

CHEMICAL NAME :: Platinum(IV), diamminetetrachloro-, (Z)-

CAS REGISTRY NUMBER :: 16893-05-3

LAST UPDATED :: 199410

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: Cl4-H6-N2-Pt

MOLECULAR WEIGHT :: 370.97

WISWESSER LINE NOTATION :: .PT..Z&2.G4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 22840 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 26820 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 50 umol/L

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 10,27,1975

Safety Information

[ Symbol ]:

GHS05, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H317-H318-H334

[ Precautionary Statements ]:
Missing Phrase - N15.00950417-P261-P280-P284-P305 + P351 + P338 + P310

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S26;S36

[ RIDADR ]:
UN 2811

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Articles

Induction and repair of DNA cross-links in chinese hamster ovary cells treated with various platinum coordination compounds in relation to platinum binding to DNA, cytotoxicity, mutagenicity, and antitumor activity.

Cancer Res. 44(5) , 2043-51, (1984)

Several effects of four diamminechloroplatinum compounds (II and IV) in Chinese hamster ovary cells were studied. The two cis-compounds [cis-diamminedichloroplatinum(II) and cis-diamminetetrachloropla...

Toxicity, mutagenicity and induction of recA protein in Escherichia coli treated with cis-diamminedichloroplatinum(II) and cis-diamminetetrachloroplatinum(IV).

Chem. Biol. Interact. 60(2) , 207-15, (1986)

After exposure of bacteria to equal concentrations of cis-diamminedichloroplatinum(II) (DDP) and cis-diamminetetrachloroplatinum(IV) (DTP), the intracellular concentration of DTP was an order of magni...

Detection of DNA strand breaks in Escherichia coli treated with platinum(IV) antitumor compounds.

Chem. Biol. Interact. 74(3) , 343-52, (1990)

DNA strand breaks were observed in bacteria treated with Pt(IV) but not Pt(II) antitumor compounds by two methods. First, compounds which cause DNA strand breaks produced an SOS induction signal which...