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H3B-6527

Names

[ CAS No. ]:
1702259-66-2

[ Name ]:
H3B-6527

[Synonym ]:
2-Propenamide, N-[2-[[6-[[[(2,6-dichloro-3,5-dimethoxyphenyl)amino]carbonyl]methylamino]-4-pyrimidinyl]amino]-5-(4-ethyl-1-piperazinyl)phenyl]-
N-{2-[(6-{[(2,6-Dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}-4-pyrimidinyl)amino]-5-(4-ethyl-1-piperazinyl)phenyl}acrylamide

Biological Activity

[Description]:

H3B-6527 (H3 Biomedicine) is a highly selective FGFR4 inhibitor with potent antitumour activity in FGF19 amplified cell lines and mice.

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Dimitra Repana et al. Targeting FGF19/FGFR4 Pathway: A Novel Therapeutic Strategy for Hepatocellular Carcinoma. Diseases 2015, 3, 294-305;


[Related Small Molecules]

Nintedanib (BIBF 1120) | Infigratinib (BGJ398) | AZD4547 | PD173074 | Erdafitinib(JNJ-42756493) | FGF-401 | SU 5402 | Heparan Sulfate | Lucitanib | LY2784544 | BLU554 | Dovitinib (TKI-258, CHIR-258) | Rogaratinib | LY2874455 | BLU-9931

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
832.1±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C29H34Cl2N8O4

[ Molecular Weight ]:
629.537

[ Flash Point ]:
457.0±34.3 °C

[ Exact Mass ]:
628.208008

[ LogP ]:
4.76

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.665

[ Storage condition ]:
2-8℃

Related Compounds