Donitriptan monohydrochloride
Names
[ CAS No. ]:
170911-68-9
[ Name ]:
Donitriptan monohydrochloride
[Synonym ]:
Donitriptan hydrochloride
Donitriptan monohydrochloride
Nafadotride
Biological Activity
[Description]:
[Related Catalog]:
[Target]
5-HT1B Receptor:9.4 (pKi)
5-HT1D Receptor:9.3 (pKi)
[References]
Chemical & Physical Properties
[ Boiling Point ]:
727.1ºC at 760 mmHg
[ Molecular Formula ]:
C23H26ClN5O2
[ Molecular Weight ]:
439.94
[ Flash Point ]:
393.6ºC
[ Exact Mass ]:
439.17800
[ PSA ]:
98.38000
[ LogP ]:
3.77358
[ Vapour Pressure ]:
5.34E-21mmHg at 25°C
[ Storage condition ]:
2-8°C
MSDS
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H312-H315-H319-H332-H335
[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338
[ RIDADR ]:
UN 3439 6.1 / PGIII
Articles
Br. J. Pharmacol. 149(1) , 82-91, (2006)
It has been suggested that during a migraine attack capsaicin-sensitive trigeminal sensory nerves release calcitonin gene-related peptide (CGRP), resulting in cranial vasodilatation and central nocice...
Donitriptan (Pierre Fabre).Curr. Opin. Investig. Drugs 2(3) , 415-8, (2001)
Pierre Fabre is developing donitriptan, a piperazide 5-HT1D agonist, as a potential treatment for migraine [175854]. In January 2001, donitriptan had completed phase I trials for migraine and was sche...
Effects of donitriptan on carotid haemodynamics and cardiac output distribution in anaesthetized pigs.Cephalalgia 22(1) , 37-47, (2002)
We investigated the effects of donitriptan, which possesses a uniquely high affinity and efficacy at 5-HT1B/1D receptors, on carotid and systemic haemodynamics in anaes thetized pigs. Donitriptan (0.1...