PD158780
Names
[ CAS No. ]:
171179-06-9
[ Name ]:
PD158780
[Synonym ]:
N4-(3-Bromophenyl)-N6-methylpyrido[3,4-d]pyrimidine-4,6-diamine
PD158780
Biological Activity
[Description]:
[Related Catalog]:
[Target]
EGFR:8 μM (IC50, Cell Assay)
ErbB2:49 nM (IC50, Cell Assay)
ErbB3:52 nM (IC50, Cell Assay)
ErbB4:52 nM (IC50, Cell Assay)
[In Vitro]
[In Vivo]
[Kinase Assay]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.611g/cm3
[ Boiling Point ]:
499.6ºC at 760 mmHg
[ Melting Point ]:
176 °C
[ Molecular Formula ]:
C14H12BrN5
[ Molecular Weight ]:
330.18300
[ Flash Point ]:
255.9ºC
[ Exact Mass ]:
329.02800
[ PSA ]:
62.73000
[ LogP ]:
3.71860
[ Vapour Pressure ]:
4.1E-10mmHg at 25°C
[ Index of Refraction ]:
1.768
MSDS
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ RIDADR ]:
NONH for all modes of transport
[ HS Code ]:
2933990090
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Neuropsychopharmacology 40(4) , 974-86, (2015)
Anxiety disorder is related to the pathophysiology of psychiatric diseases, including major depression, substance abuse, and schizophrenia. The amygdala is important for manifestation and modulation o...