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Oleanolic acid derivative 1

Names

[ CAS No. ]:
1724-18-1

[ Name ]:
Oleanolic acid derivative 1

[Synonym ]:
Methyl (3aR,5aR,5bS,7aS,11aS,13aR,13bS)-3-isopropylidene-5a,5b,10,10,13b-pentamethyl-1,2,3,3a,4,5,5a,5b,6,7,8,9,10,11,11a,13,13a,13b-octadecahydro-7aH-cyclopenta[a]chrysene-7a-carboxylate
7aH-Cyclopenta[a]chrysene-7a-carboxylic acid, 1,2,3,3a,4,5,5a,5b,6,7,8,9,10,11,11a,13,13a,13b-octadecahydro-5a,5b,10,10,13b-pentamethyl-3-(1-methylethylidene)-, methyl ester, (3aR,5aR,5bS,7aS,11aS,13aR,13bS)-

Biological Activity

[Description]:

Oleanolic acid derivative 1 is an oleanolic acid derivative, which is a novel triterpenoid-steroid hybrid molecule.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[In Vitro]

Oleanolic acid suppress transcription or translation of inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) genes. HY-18002 is extracted from the reference, compound 9a. In the strategy, it was ambiguous whether phosphorus pentachloride (PCl5) would give the desired ring contraction product 9a (HY-18002) in the first step according to classical procedures[1].

[References]

[1]. Tadashi Honda, et al. Design and Synthesis of 23,24-Dinoroleanolic Acid Derivatives, Novel Triterpenoid-Steroid Hybrid Molecules. J. Org. Chem., 1998, 63 (14), pp 4846-4849.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
503.3±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C31H48O2

[ Molecular Weight ]:
452.712

[ Flash Point ]:
255.1±17.7 °C

[ Exact Mass ]:
452.365417

[ LogP ]:
11.13

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.540

[ Storage condition ]:
2-8℃

Related Compounds