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PB 28 dihydrochloride

Names

[ CAS No. ]:
172907-03-8

[ Name ]:
PB 28 dihydrochloride

[Synonym ]:
1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-1-naphthalenyl)propyl]piperazine dihydrochloride
PB28 dihydrochloride
1-Cyclohexyl-4-(3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-n-propyl)piperazine dihydrochloride
MFCD06798349
Piperazine, 1-cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]-, hydrochloride (1:2)

Biological Activity

[Description]:

A potent, mixed sigma2 agonist and sigma1 antagonist with Ki of 0.28 and 13.0 nM, respectively; inhibits cancer cell growth, modulates P-glycoprotein, and synergizes with doxorubicin in MCF7 and MCF ADR cells with IC50 in nanomolar range; increase G0-G1-phase fraction and caspase-independent apoptosis, also reduces P-gp expression.

[References]

References 1. Azzariti A, et al. Mol Cancer Ther. 2006 Jul;5(7):1807-16. 2. Cassano G, et al. Cell Calcium. 2006 Jul;40(1):23-8. 3. Berardi F, et al. J Med Chem. 1996 Jan 5;39(1):176-82. View Related Products by Target Sigma Receptor

Chemical & Physical Properties

[ Molecular Formula ]:
C24H40Cl2N2O

[ Molecular Weight ]:
443.493

[ Exact Mass ]:
442.251770

Related Compounds