XR 5118
Names
[ CAS No. ]:
174766-49-5
[ Name ]:
XR 5118
Biological Activity
[Description]:
XR 5118 is a small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 3.5 uM, binds to PAI-1 and reduces plasma PAI-1 activity levels, promotes endogenous thrombolysis and inhibits thrombus accretion; the first nonpeptide compound with significant anti-PAI-1 activity in vivo. Thrombosis Discontinued
[References]
References 1. Friederich PW, et al. Circulation. 1997 Aug 5;96(3):916-21. 2. Einholm AP, et al. Biochem J. 2003 Aug 1;373(Pt 3):723-32. 3. Folkes A, et al. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2589-92. View Related Products by Target Plasminogen Activator Inhibitor-1 (PAI-1) Thrombosis
Chemical & Physical Properties
[ Molecular Formula ]:
C20H22ClN3O2S2
[ Molecular Weight ]:
435.985