16-BETA-HYDROXYTESTOSTERONE

Names

[ Name ]:
16-BETA-HYDROXYTESTOSTERONE

[Synonym ]:
(8R,9S,10R,13S,14S,16S,17R)-16,17-dihydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

Chemical & Physical Properties

[ Density]:
1.19g/cm3

[ Boiling Point ]:
454.7ºC at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₈O₃

[ Molecular Weight ]:
304.42400

[ Flash Point ]:
242.9ºC

[ Exact Mass ]:
304.20400

[ PSA ]:
57.53000

[ LogP ]:
2.85000

[ Vapour Pressure ]:
3.53E-10mmHg at 25°C

[ Index of Refraction ]:
1.578

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H351-H360

[ Precautionary Statements ]:
P201-P281-P308 + P313

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ RIDADR ]:
NONH for all modes of transport

Articles

Moderate coffee and alcohol consumption improves the estrogen metabolite profile in adjuvant treated breast cancer patients: a pilot study comparing pre- and post-operative levels.

Mol. Genet. Metab. 89(4) , 381-9, (2006)

Most, but not all, studies have found that women with a high urinary 2-hydroxyestrogen (2OHE) to 16alpha-hydroxyestrone (16alphaOHE1) ratio are at reduced risk for breast cancer and have a better prog...

Permissive and suppressive effects of dexamethasone on enzyme induction in hepatocyte co-cultures.

Xenobiotica 32(8) , 653-66, (2002)

1. Steroids are known to act as permissive factors in hepatocytes. This study shows that dexamethasone (DEX) is a permissive factor for induction of CYP2B1/2, CYP3A1, CYP2A1 and probably also CYP2C11 ...

Theoretical kinetics of sequential metabolism in vitro. Study of the formation of 16 alpha-hydroxyandrostenedione from testosterone by purified rat P450 2C11.

Drug Metab. Dispos. 22(4) , 584-91, (1994)

P450 2C11 from rat liver is known to metabolize testosterone to 2 alpha-, 16 alpha-, and 6 beta-hydroxytestosterone, and to androstenedione and 16 alpha-hydroxyandrostenedione. Because Waxman (J. Biol...