2-Phenoxyethanamine
Names
[ CAS No. ]:
1758-46-9
[ Name ]:
2-Phenoxyethanamine
[Synonym ]:
2-Phenoxyethanamine
4-Aminophenetole
p-Phenetidine
EINECS 217-153-6
2-Phenoxy-ethylamine
Ethanamine, 2-phenoxy-
Phenetidine
MFCD00052975
4-Ethoxyaniline
2-phenoxyethylamino
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
230.3±23.0 °C at 760 mmHg
[ Molecular Formula ]:
C8H11NO
[ Molecular Weight ]:
137.179
[ Flash Point ]:
97.9±15.9 °C
[ Exact Mass ]:
137.084061
[ PSA ]:
35.25000
[ LogP ]:
0.89
[ Vapour Pressure ]:
0.1±0.5 mmHg at 25°C
[ Index of Refraction ]:
1.527
[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KR9500000
- CHEMICAL NAME :
- Ethylamine, 2-phenoxy-
- CAS REGISTRY NUMBER :
- 1758-46-9
- BEILSTEIN REFERENCE NO. :
- 0774671
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C8-H11-N-O
- MOLECULAR WEIGHT :
- 137.20
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 95 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - central sympatholytic Vascular - BP lowering not characterized in autonomic section
- REFERENCE :
- 85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,172,1948
Safety Information
[ Symbol ]:
GHS05
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H314
[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
C:Corrosive;
[ Risk Phrases ]:
R34
[ Safety Phrases ]:
S26-S36/37/39-S45
[ RIDADR ]:
UN 2735 8/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
KR9500000
[ Packaging Group ]:
III
[ Hazard Class ]:
8
[ HS Code ]:
2922299090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2922299090
[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
Angew. Chem. Int. Ed. Engl. 49(19) , 3360-2, (2010)
Syntheses of 1,4-benzothiazepines and 1,4-benzoxazepines via cyclizations of 1-[2-arylthio(oxy)ethyl]-5-benzotriazolyl-2-pyrrolidinones and 3-benzotriazolyl-2-[2-arylthio(oxy)ethyl]-1-isoindolinones.
J. Org. Chem. 66(16) , 5590-4, (2001)
1-[2-Arylthio(oxy)ethyl]-5-benzotriazolyl-2-pyrrolidinones 6a-e, 12 and 3-benzotriazolyl-2-[2-arylthio(oxy)ethyl]-1-isoindolinones 9a-f, 14 are readily available from reactions of benzotriazole (4), 2...
Stable gaseous aziridinium ions. Van de Sande CC, et al.Org. Mass Spectrom. 13(11) , 666-70, (1978)