Bis(4-aminocyclohexyl)methane

Names

[ Name ]:
Bis(4-aminocyclohexyl)methane

[Synonym ]:
4,4-Methylenebiscyclohexylamine
hlr4448
4,4'-methanediyldicyclohexanamine
bis(para-amino-cyclohexyl)methane
Cyclohexanamine, 4,4'-methylenebis-
EINECS 217-168-8
Bis(4-aminocyclohexyl)methane
Wondamine HM
p-aminodicyclohexylmethane
DICYKAN
HLR 4219
4,4'-Methylenebis(aminocyclohexane)
4,4'-Methylenedicyclohexanamine
TRANS,TRANS-4,4'-METHYLENEBIS(CYCLOHEXYLAMINE)
4,4'-Methylenebis(cyclohexylaMine)
4,4'-Diaminodicyclohexylmethane
4,4'-methylene bis(cyclohexylamine)
4-((4-aminocyclohexyl)methyl)cyclohexanamine
Bis-(p-aminocyclohexyl)methane
MFCD00001496
di(4-aminocyclohexyl)-methane
4,4-Methylenebis(Cyclohexylamine)
bis-(4-amino cyclohexyl)-methane
PACM20
wandaminhm
Amicure PACM

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
320.0±0.0 °C at 760 mmHg

[ Melting Point ]:
60-65°C

[ Molecular Formula ]:
C₁₃H₂₆N₂

[ Molecular Weight ]:
210.359

[ Flash Point ]:
144.8±17.9 °C

[ Exact Mass ]:
210.209595

[ PSA ]:
52.04000

[ LogP ]:
2.49

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.499

[ Water Solubility ]:
Insoluble (

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GX1530000

CHEMICAL NAME :: Cyclohexylamine, 4,4'-methylenebis-

CAS REGISTRY NUMBER :: 1761-71-3

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C13-H26-N2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 670 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571204

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,481,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 20175 mg/kg/1.5Y-I

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of salivary glands Liver - fatty liver degeneration Kidney, Ureter, Bladder - interstitial nephritis

REFERENCE :: JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 11,367,1991

Safety Information

[ Symbol ]:

GHS05, GHS07, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H314-H317-H373-H411

[ Precautionary Statements ]:
P273-P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+:Verytoxic;N:Dangerous for the environment;

[ Risk Phrases ]:
R26;R34;R51/53

[ Safety Phrases ]:
S26-S28-S36/37/39-S45-S61

[ RIDADR ]:
UN 2928 6.1/PG 2

[ WGK Germany ]:
2

[ RTECS ]:
GX1530000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2921300090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Preparation

Customs

[ HS Code ]: 2921300090

[ Summary ]:
2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Allergic contact dermatitis from dicyclohexylmethane-4,4'-diisocyanate.

Contact Dermatitis 48(6) , 305-9, (2003)

From August 1999 to April 2001, there was an outbreak of severe eczema at a factory manufacturing medical equipment. A glue, mainly based on the isocyanate dicyclohexylmethane-4,4'-diisocyanate (DMDI)...

Toxicity of 1,4-bis(aminocyclohexyl)methane.

J. Appl. Toxicol. 11(5) , 367-71, (1991)

1,4-Bis(aminocyclohexyl)methane (PACM; CAS No. 1761-71-3) is a white solid considered for use in polymeric systems. PACM is moderately toxic systemically, with the acute oral lethal dose in rats betwe...