Trimethylsulfoxonium iodide

Names

[ Name ]:
Trimethylsulfoxonium iodide

[Synonym ]:
Trimethyl sulphoxonium ioidie
OS1&1&1 &&iodide
Trimethylsulfoxonium Iodide
Trimethyloxosulfonium iodide
trimethyl-oxo-sulfonium iodide
trimethyloxosulphonium iodide
MFCD00011899
trimethyl sulphoxonium iodide
dimethyloxosulfonium methylide
Corey-Chaykovsky reagent
EINECS 217-204-2
S,S,S-Trimethylsulfoxonium iodide
Sulfoxonium,trimethyl-,iodide

Chemical & Physical Properties

[ Melting Point ]:
208-212 °C (dec.)(lit.)

[ Molecular Formula ]:
C₃H₉IOS

[ Molecular Weight ]:
220.072

[ Exact Mass ]:
219.941864

[ PSA ]:
36.28000

[ Water Solubility ]:
15 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WS3585000

CHEMICAL NAME :: Sulfoxonium, trimethyl-, iodide

CAS REGISTRY NUMBER :: 1774-47-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C3-H9-O-S.I

MOLECULAR WEIGHT :: 220.08

WISWESSER LINE NOTATION :: OS1&1&1 &Q &I

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IJRBA3 International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine. (Taylor & Francis Inc., 242 Cherry St., Philadelphia, PA 19106) V.1- 1959- Volume(issue)/page/year: 3,41,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04108

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S37/39-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
WS3585000

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909199090

[ Summary ]:
2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

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Tetrahedron 50 , 9157, (1994)

Renin inhibitors containing C-termini derived from mercaptoheterocycles.

J. Med. Chem. 35 , 2103, (1992)

A series of transition-state analogues having heterocyclythio C-termini has been synthesized and evaluated for inhibition of human renin. Addition of mercaptoheterocycles to a chiral Boc-amino epoxide...

Tetrahedron 49 , 5067, (1993)