2,4,5,6-Tetrachloropyrimidine

Names

[ Name ]:
2,4,5,6-Tetrachloropyrimidine

[Synonym ]:
Perchloropyrimidine
2,4,5,6-Tetrachloro-1,3-pyrimidine
Tetrachlor-pyrimidin
2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBOTHIOAMIDE
Tetrachloropyrimidine
MFCD00006062
2,4,5,6-TetrachloropyriMidine
EINECS 217-228-3
Pyrimidine,tetrachloro
2,4,5,6-tetrachloro-pyrimidine

Chemical & Physical Properties

[ Density]:
1.761g/cm3

[ Boiling Point ]:
108-112ºC (12 mmHg)

[ Melting Point ]:
60-62ºC

[ Molecular Formula ]:
C₄Cl₄N₂

[ Molecular Weight ]:
217.86800

[ Flash Point ]:
133.2ºC

[ Exact Mass ]:
215.88200

[ PSA ]:
25.78000

[ LogP ]:
3.09020

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV9745000

CHEMICAL NAME :: Pyrimidine, 2,4,5,6-tetrachloro-

CAS REGISTRY NUMBER :: 1780-40-1

BEILSTEIN REFERENCE NO. :: 0145778

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C4-Cl4-N2

MOLECULAR WEIGHT :: 217.86

WISWESSER LINE NOTATION :: T6N CNJ BG DG EG FG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#07768

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
UN 2811

[ WGK Germany ]:
3

[ RTECS ]:
UV9745000

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis of Aryl-Substituted Pyrimidines by Site-Selective Suzuki-Miyura Cross-Coupling Reactions of 2, 4, 5, 6-Tetrachloropyrimidine. Hussain M, et al.

Adv. Synth. Catal. 352(9) , 1429-33, (2010)

Facile assembly of fused benzo[4,5]furo heterocycles.

J. Org. Chem. 73(7) , 2951-4, (2008)

A concise synthesis of fused benzo[4,5]furo heterocycles 18 has been developed. Chemo/regioselective Suzuki coupling between 1,2-dihaloarene 17 and alpha-hydroxyphenylboronic acid or ester 20 gives bi...